RPSFT - metoda analýzy přežití pro studie umožňující pacientům přechod na účinnější léčbu (treatment switch)

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Title in English RPSFT - survival analysis method for studies enabling patients transition to more effective treatment (treatment switch)
Authors

SVOBODNÍK Adam ANTONOVA Mariya ŠTĚPÁNOVÁ Radka KÝR Michal

Year of publication 2021
Type Article in Periodical
Magazine / Source Farmakoterapie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.farmakoterapie.cz/c7016/rpsft-metoda-analyzy-preziti-pro-studie-umoznujici-pacientum-prechod-na-ucinnejsi-lecbu-treatment-switch
Keywords Survival Analysis; treatment switch; clinical studies
Attached files
Description In clinical trials, comparing the efficacy of treatments "treatment switch "or "cross-over "between treatments could happen. Typical examples of treatment switch are in oncology when after the failure of a treatment switch to another treatment is allowed. In the analysis of overall survival, treatment switch could lead to overestimating control treatment effect. Several statistical techniques were developed to avoid this bias to face the problem. The most frequently used technique is RPSFT (Rank Preserving Structural Failure Time).
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.