Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

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Authors

JELÍNEK Matyáš JURAJDA Michal ĎURIŠ Kamil

Year of publication 2021
Type Article in Periodical
Magazine / Source Antioxidants
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2076-3921/10/12/1886
Doi http://dx.doi.org/10.3390/antiox10121886
Keywords oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers
Description The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.
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