Deriváty hydroxamových kyselin jako inhibitory histondeacetyláz

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Pharmacy. Official publication website can be found on muni.cz.
Title in English Hydroxamic acid derivatives as histone deacetylase inhibitors
Authors

KAUEROVÁ Tereza KOLLÁR Peter

Year of publication 2021
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Histone deacetylase inhibitors are substances whose antitumor activity is associated with inhibition of cell proliferation, induction of programmed cell death, inhibition of angiogenesis, and induction of the cytodifferentiation process in tumor cells. Effective inhibitors of histone deacetylase enzymes include hydroxamic acids. In this group you can find registered anticancer drugs, among which it is possible to name eg vorinostat or panobinostat. In vitro analyzes of the antiproliferative and proapoptotic effects of vorinostat on selected types of leukemic cells demonstrated the sensitivity of the monocyte leukemic cell line THP-1 to this effect of vorinostat, including induction of cytodifferentiation.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.