Five gene polymorphism in T-cell lymphoma

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Authors

VAŠKŮ Vladimír VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie ZNOJIL Vladimír SEMRÁDOVÁ Věra

Year of publication 1999
Type Article in Periodical
Magazine / Source Journal of the European Academy of Dermatology and Venerology
MU Faculty or unit

Faculty of Medicine

Citation
Field Dermatovenerology
Keywords CTCL; gene polymorphism; angiotensinogen; TNF beta; endothelin-1; angiotensinogen
Description The aim of the study was to compare 33 patients with CTCL and 66 healthy control subjects in five gene polymorphisms (I/D ACE, M235T ATG, A(-6)G ATG, G(8002)A ET-1 and NcoI TNF beta). The case control difference was proved in coincidence od I/D ACE and TNF beta double genotype (P=0.017) which was done especially by substantially higher coincidence of DD genotype (I/D ACE) with B1B2 genotype of TNF beta (P=0.002).
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