Olanzapine concentrations in dried blood spot vs. plasma
| Authors | |
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| Year of publication | 2022 |
| Type | Conference abstract |
| Citation | |
| Description | Olanzapine (OLA) is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar disorder nearly 20 years ago. Therapeutic drug monitoring is strongly recommended according to the Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology, and the therapeutic range of 20 to 80 ng/mL in plasma has been proposed. Dried blood spot (DBS) represents mini-invasive microsampling method, but no reference range has been established yet. The developed LC-MS method offers short analysis cycle time (12 min) with satisfactory sensitivity covering recommended OLA therapeutic concentration range in both types of samples (plasma and DBS). Primary patient plasma and DBS samples were acquired, quantified and preliminary comparison results were derived. |
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