Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | FRONTIERS IN ONCOLOGY |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.frontiersin.org/articles/10.3389/fonc.2022.1073036/full |
| Doi | http://dx.doi.org/10.3389/fonc.2022.1073036 |
| Keywords | high-grade glioma; glioblastoma; anaplastic astrocytoma; wound infection; prolonged survival |
| Description | High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection. |
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