Johann Gregor Mendel: the victory of statistics over human imagination

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Authors

RAUDENSKÁ Martina VIČAR Tomáš GUMULEC Jaromír MASAŘÍK Michal

Year of publication 2023
Type Article in Periodical
Magazine / Source European Journal of Human Genetics
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41431-023-01303-1
Doi http://dx.doi.org/10.1038/s41431-023-01303-1
Keywords Johann Gregor Mendel
Attached files
Description In 2022, we celebrated 200 years since the birth of Johann Gregor Mendel. Although his contributions to science went unrecognized during his lifetime, Mendel not only described the principles of monogenic inheritance but also pioneered the modern way of doing science based on precise experimental data acquisition and evaluation. Novel statistical and algorithmic approaches are now at the center of scientific work, showing that work that is considered marginal in one era can become a mainstream research approach in the next era. The onset of data-driven science caused a shift from hypothesis-testing to hypothesis-generating approaches in science. Mendel is remembered here as a promoter of this approach, and the benefits of big data and statistical approaches are discussed.
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