SCHIFF BASES AS POTENTIAL THERAPEUTIC AGENTS

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Authors	BALLAYOVÁ Veronika KAUEROVÁ Tereza KOLLÁR Peter FARSA Oldřich
Year of publication	2023
Type	Appeared in Conference without Proceedings
MU Faculty or unit	Faculty of Pharmacy
Citation
Description	Schiff bases, which are carrying imine or azomethine functional group, are versatile pharmacophores capable of forming chelating complexes with various metals. Metal complexes play a crucial role in pharmaceutical sciences due to their wide and significant activities.1 Synthesized basic thiosemicarbazone and semicarbazone derivatives of acetophenone may be bioactive compounds as well. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
Related projects:	Interní grantová agentura Masarykovy univerzity Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs