Structural conservation of antibiotic interaction with ribosomes

Investor logo
Investor logo

Warning

This publication doesn't include Faculty of Arts. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

PATERNOGA Helge CROWE-MCAULIFFE Caillan BOCK Lars V KOLLER Timm O MORICI Martino BECKERT Bertrand MYASNIKOV Alexander G GRUBMUELLER Helmut NOVÁČEK Jiří WILSON Daniel N

Year of publication 2023
Type Article in Periodical
Magazine / Source NATURE STRUCTURAL & MOLECULAR BIOLOGY
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.nature.com/articles/s41594-023-01047-y
Doi http://dx.doi.org/10.1038/s41594-023-01047-y
Keywords ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies
Description Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.