State analysis of fMRI in amnestic mild cognitive impairment

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Authors	GAJDOŠ Martin NOVÁKOVÁ Marie LAMOŠ Martin ŘÍHA Pavel REKTOROVÁ Irena MIKL Michal
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Amnestic mild cognitive impairment (aMCI) is transitional state between normal aging and early dementia. In this work, we studied dynamic functional connectivity captured with sliding window analysis, whoch was performed on a dataset of 76 subjects (38 HC + 38 aMCI). We found significant differences in coverage in 2 out of 4 identified states. Moreover, with support vector machine, we were able to discriminate between these two groups with approx. 95% accuracy. In future work, we plan to crossvalidate presented classifier. Amnestic mild cognitive impairment (aMCI) is transitional state between normal aging and early dementia. In this work, we studied dynamic functional connectivity captured with sliding window analysis, whoch was performed on a dataset of 76 subjects (38 HC + 38 aMCI). We found significant differences in coverage in 2 out of 4 identified states. Moreover, with support vector machine, we were able to discriminate between these two groups with approx. 95% accuracy. In future work, we plan to crossvalidate presented classifier.
Related projects:	Biomarkers of neurodegenerative diseases based on dynamic functional connectivity