Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model

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Authors	HORSKÁ Kateřina KUČERA Jan DRAŽANOVÁ Eva KUZMÍNOVÁ Gabriela AMCHOVÁ Petra HRICKOVÁ Mária RUDÁ Jana SKREDE Silje
Year of publication	2024
Type	Article in Periodical
Magazine / Source	Biomedicine and Pharmacotherapy
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.sciencedirect.com/science/article/pii/S0753332224006474
Doi	http://dx.doi.org/10.1016/j.biopha.2024.116763
Keywords	Antipsychotic; Olanzapine; metabolic adverse effects; GLP-1 receptor agonist; Schizophrenia
Description	A combined strategy of dulaglutide and food restriction manifested a massive synergistic benefit. GLP-1RAs represent a promising strategy and deserve thorough future research. Our findings underline the potential importance of lifestyle intervention in addition to GLP-1 RA treatment.
Related projects:	National research infrastructure for biological and medical imaging Pharmacological reversal of metabolic derrangements induced by antipsychotic treatment in animal models Preklinický vývoj terapeutických přístupů k redukci nežádoucích metabolických účinků atypických antipsychotik Pharmacological reversal of metabolic derangements induced by antipsychotic treatment in animal models: intensification of the collaboration Czech BioImaging: National research infrastructure for biological and medical imaging Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology