Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

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Authors

FRESCURA Francesca ŠTARK Tibor TIZIANI Edoardo DI MARTINO Serena RUDÁ Jana DRAGO Filippo FERRARO Luca MICALE Vincenzo BEGGIATO Sarah

Year of publication 2024
Type Article in Periodical
Magazine / Source PHARMACOLOGICAL REPORTS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://link.springer.com/article/10.1007/s43440-024-00604-6
Doi http://dx.doi.org/10.1007/s43440-024-00604-6
Keywords AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia
Description The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.
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