RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

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Authors

BUGAJOVÁ Mária RAUDENSKÁ Martina MASAŘÍK Michal KALFERT David BETKA Jan BALVAN Jan

Year of publication 2024
Type Article in Periodical
Magazine / Source International journal of cancer
MU Faculty or unit

Faculty of Medicine

Citation
web https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035
Doi http://dx.doi.org/10.1002/ijc.35035
Keywords metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment
Description Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.
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