Exploring BPA alternatives - Environmental levels and toxicity review

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Authors

ADAMOVSKÝ Ondřej GROH Ksenia J. BIALK-BIELINSKA Anna ESCHER Beate I. BEAUDOUIN R. LAGARES Liadys Mora TOLLEFSEN Knut Erik FENSKE Martina MULKIEWICZ Ewa CREUSOT Nicolas SOSNOWSKA Anita LOUREIRO Susana BEYER Jonny REPETTO Guillermo STERN Alja LOPES Isabel MONTEIRO Marta ZIKOVA-KLOAS Andrea ELERSEK Tina VRACKO Marjan ZDYBEL Szymon PUZYN Tomasz KOCZUR Weronika MORTHORST Jane Ebsen HOLBECH Henrik CARLSSON Gunnar ORN Stefan HERRERO Oscar SIDDIQUE Ayesha LIESS Matthias BRAUN Georg SREBNY Vanessa ZEGURA Bojana HINFRAY Nathalie BRION Francois KNAPEN Dries VANDEPUTTE Ellen STINCKENS Evelyn VERGAUWEN Lucia BEHRENDT Lars SILVA Maria Joa BLÁHA Luděk KYRIAKOPOULOU Katerina

Year of publication 2024
Type Article in Periodical
Magazine / Source Environment International
MU Faculty or unit

Faculty of Science

Citation
Web https://www.sciencedirect.com/science/article/pii/S0160412024003143?via%3Dihub
Doi http://dx.doi.org/10.1016/j.envint.2024.108728
Keywords BPA alternatives; Biological activity; In silico; Invertebrates; Vertebrates
Attached files
Description Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ecological concerns. However, it can be expected that levels of BPA alternatives will dominate in the future, they are limited information on their environmental safety. The EU PARC project highlights BPA alternatives as priority chemicals and consolidates information on BPA alternatives, with a focus on environmental relevance and on the identification of the research gaps. The review highlighted aspects and future perspectives. In brief, an extension of environmental monitoring is crucial, extending it to cover BPA alternatives to track their levels and facilitate the timely implementation of mitigation measures. The biological activity has been studied for BPA alternatives, but in a non-systematic way and prioritized a limited number of chemicals. For several BPA alternatives, the data has already provided substantial evidence regarding their potential harm to the environment. We stress the importance of conducting more comprehensive assessments that go beyond the traditional reproductive studies and focus on overlooked relevant endpoints. Future research should also consider mixture effects, realistic environmental concentrations, and the long-term consequences on biota and ecosystems.
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