Restoration of lamellar structures in adult rat Pacinian corpuscles following their simultaneous freezing injury and denervation

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Authors

DUBOVÝ Petr

Year of publication 2000
Type Article in Periodical
Magazine / Source Anatomy and Embryology
MU Faculty or unit

Faculty of Medicine

Citation
Field Morphological specializations and cytology
Keywords inner core; Schwann cells
Description The capsule and inner core are multilamellar auxiliary structures enveloping the axon terminal of the Pacinian corpuscle. The freezing injury of the rat interosseal Pacinian corpuscles induced the destruction of all cellular components while the extracellular matrix including the basal laminae survive the treatment. Simultaneous denervation and the freezing treatment of the Pacinian corpuscles discovered an ability of the basal lamina and other components of the extracellular matrix to stimulate a differentiation of migrated Schwann cells and fibroblasts into multilamellar auxiliary structures. The restoration of inner core and capsule in the Pacinian corpuscles was independent of the presence of sensory axon terminals. The restored lamellar structures of Pacinian corpuscles in long-term surviving rat (4 to 8 months) displayed atrophic changes. The results suggest that the extracellular matrix of rat Pacinian corpuscles may contain molecules which are produced by Schwann cells and fibroblasts during maturation of the multilamellar auxiliary structures. The molecules deposited into the extracellular matrix are able to influence the re-differentiation of multilamellar auxiliary structures from immature cells.
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