Factor V Leiden in Patients with recurrent Fetal Loss

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Authors

DRÁBKOVÁ Marie VOJTÍŠKOVÁ Marie VAŠKŮ Anna BURNOG Tomáš JANKŮ Petr KAŇKOVÁ Kateřina

Year of publication 2000
Type Article in Proceedings
Conference Book of Abstracts of XVI. FIGO World Congress
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords Factor V Leiden; fetal loss
Description S u m m a r y: The factor V Leiden mutation is the most common genetic predisposition to thrombosis. Our purpose was to determine the association of Factor V Leiden mutation (FVL) frequency and recurrent fetal loss.We examined the prevalence of the point mutation in the factor V gene (R 506 Q or Leiden) in 138 unselected women with a history of one or more spontaneous abortion or stillbirth of unexplained etiology. In our referral population women, a statistically significant association of the Leiden mutation with recurrent fetal losses was found. The risk for recurrence of fetal loss tended to be greater in homozygous carriers.
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