Rozdíl behaviorálních účinků po akutním a chronickém podání metamfetaminu u myší

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Title in English Changes of methamphetamine behavioural activity in mice after acute and repeated administration
Authors

VINKLEROVÁ Jana NOVÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2000
Type Article in Periodical
Magazine / Source Československá fyziologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Description The present study investigated the influence of methamphetamine, a derivate of amphetamine with more potent psychostimulatory effects,on the behavioural activity. Three minute dyadic behavioural interactions of singly-housed mice with non aggressive group-housed parters were video-taped and the analysis was processed using the computer-compatible system (THE OBSERVER 3.1.). Acute subcutaneous administration of methamphetamine (1, 5 and 10mg/kg) inhibited aggressivity and increased locomotor activity. Repeated (13x) subcutaneous administration of methamphetamine (1mg/kg) did not proved this effect.
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