Rozdíl behaviorálních účinků po akutním a chronickém podání metamfetaminu u myší
| Title in English | Changes of methamphetamine behavioural activity in mice after acute and repeated administration |
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| Authors | |
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Československá fyziologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Description | The present study investigated the influence of methamphetamine, a derivate of amphetamine with more potent psychostimulatory effects,on the behavioural activity. Three minute dyadic behavioural interactions of singly-housed mice with non aggressive group-housed parters were video-taped and the analysis was processed using the computer-compatible system (THE OBSERVER 3.1.). Acute subcutaneous administration of methamphetamine (1, 5 and 10mg/kg) inhibited aggressivity and increased locomotor activity. Repeated (13x) subcutaneous administration of methamphetamine (1mg/kg) did not proved this effect. |
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