Vliv agonistů 5HT1 receptorů na aktivitu CYP 2D a N-acetyltransferázy (NAT2) v izolovaných perfundovaných játrech potkana

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Title in English	Influence of 5HT1 receptor agonists on activity of cytochrome P450 2D and arylamine N-acetyltransferase in the isolated perfused rat liver
Authors	JUSTINOVÁ Zuzana PISTOVČÁKOVÁ Jana TOMANDLOVÁ Marie HADAŠOVÁ Eva
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Description	5HT1 receptor is largely involved in ethiology od psychiatric and other disorders. The study was performed to answer whether selected 5HT1 agonists (CGS 12066B,RU 24969, sumatriptan) might interfere with hepatic drug metabolizing enzymes in the isolated perfused rat liver. The results showed that CGS 12066B and RU-24969 significantly inhibited the activity of cytochrome P450 2D1; the NAT activity was slightly decreased by CGS 12066B and sumatriptan.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems