Aktivita cytochromu P450-2D6 a N-acetyltransferázy v izolovaných perfundovaných játrech potkana po podání agonistů 5-HT receptorů

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Title in English Activity of cytochrome P450-2D6 a N-acetyltransferase in the isolated perfused rat liver after administration of agonists of 5-HT receptors
Authors

JUSTINOVÁ Zuzana PISTOVČÁKOVÁ Jana TOMANDLOVÁ Marie HADAŠOVÁ Eva

Year of publication 2000
Type Article in Periodical
Magazine / Source Československá fyziologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Cytochrome P450; N-acetyltransferase; 5-HT1 agonists; rat; liver
Description Influence of selected agonists of 5-HT1 receptors on the activity of CYP 2D and NAT2 was followed in the isolated liver of rat donors. The results showed that RU-24969 and CGS 12066B inhibited the CYP2D activity, but they did not affect NAT2 activity. Sumatriptan slightly inhibited NAT2 activity and did not influence the oxidative metabolism in the liver.
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