Segregation of nucleolar components coicides with caspase-3 activation in cisplatin-treated HeLa cells

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Authors

HORKÝ Marcel WURZER Gabriele KOTALA Vladimír ANTON Milan VOJTĚŠEK Bořivoj VÁCHA Jiří WESIERSKA-GADEK Jozefa

Year of publication 2001
Type Article in Periodical
Magazine / Source Journal of Cell Science
MU Faculty or unit

Faculty of Medicine

Citation
Field Morphological specializations and cytology
Description We studied morphological changes of the nucleoli in HeLa cells traeted with cisplatin and compared them with induction of markers of programmed cell death and TUNEL staining. Remarkable segregation of nucleolar argyrophillic proteins, nucleolar RNA and a simultaneous activation of the cascade od caspases markedly preceded the TUNEL positivity in cisplatin-treated heLa cells.
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