ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Am.J.Respir.Crit.Care Med |
| MU Faculty or unit | |
| Citation | |
| Field | Pneumology |
| Keywords | gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility |
| Description | Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations. |
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