Vedlejší účinky léčby paroxetinem v závislosti na aktivitě CYP 2D6

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Title in English	The relation of side-effects of treatment by paroxetine to CYP 2D6 activity
Authors	ŽOURKOVÁ Alexandra HADAŠOVÁ Eva VÁVROVÁ Marta ROBEŠ Miroslav VOJTÍŠKOVÁ Marie
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	side effects; paroxetine; CYP 2D6; poor metabolizer; extensive metabolizer
Description	The paper is a comparison of the incidence of side effects of treatment by paroxetine in a group of 20 patients as evaluated according to the UKU scale, between patients with the CYP 2D6 phenotype conversion and those in whom the conversion wat not observed. A statistically significance (the chi quadrate test), was found only in association with sexual dysfunction where bad metabolisers were worse off.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems