Immunohistochemical differences in the ECM content alongside afferent and motor axons in relation to the position of the dorsal root ganglion
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | The Histochemical Journal |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Description | The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour during peripheral nerve formation and homeostasis. Composition of the ECM is the major determinant of the microenvironmental condition that controls the nerve regeneration. To reveal different microenvironmental conditions for motor and afferent axons we have analysed immunohistochemically some ECM components and adhesion molecules (laminin-2, -3, fibronectin, thrombospondin, tenascin, chondroitin sulphate, and HNK-1) in the spinal roots and branches of the spinal nerve. The results of quantitative immunofluorescence analysis suggest some differences in the content of ECM along the afferent and motor axons that could be involved in the origin of different conditions for the axon regrowth after injury of the dorsal and ventral roots as well as the spinal nerves. |
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