One-pot Synthesis of N1-(2-Phenyl-4-quinazolinyl)-2--R-1-hydrazinecarbothioamide

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Authors

MOHAMED Walid Fathalla PAZDERA Pavel

Year of publication 2001
Type Article in Proceedings
Conference Sborník príspevkov 53. zjazd Chemických spoločností
MU Faculty or unit

Faculty of Science

Citation
Field Organic chemistry
Keywords Quinazolines; hydrazines; azomethines; enamines
Description The key intermediate N2-(2-cyanophenyl)-N1-thioxo-methylidenebenzene-1-carboximidamide 1 reacts in acetonitrile with N,N-disubstituted hydrazine derivatives to afford N1-(2-phenyl-4-quinazolinyl)-2,2-di-R-1-hydrazinecarbothioamide 4. On the other hand the reaction of 1 with hydrazine in acetone give N1-(2-phenyl-3,4-dihydroquinazolin-4-yliden)-1-isopropenyl-2-(1-methylethylidene)hydrazine-1-carbothioamide.
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