The regioselectivity of the thioamide moiety against electrophiles and nucleophiles
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | Sborník príspevkov 53. zjazd Chemických spoločností |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | Thioamides; thioureas; regioselectivity |
| Description | Several research workers investigated the S / N nucleophilic character competition of the thioamide moieties (included in cyclic and acyclic systems) by the intermolecular reaction with electrophiles. The discrimination between the S-alkylation and the N-alkylation were briefly published for several cases but the reason for N- and S-atoms contributions were not yet described. Our communication will simply explain the N- and S-atoms involvement in reactions on the model compound 4-methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. |
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