BEHAVIORÁLNÍ ÚČINKY FELBAMÁTU V MODELU MYŠÍCH SOCIÁLNÍCH INTERAKCÍ

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Title in English	Behavioural effect of felbamate in the agonistic model of social interactions in mice
Authors	PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	animal behaviour; antidepressant; felbamate; mouse
Description	Felbamate belongs to the antiepileptic drugs of the 3rd generation, that are known for their psychotropic effects potentially usefull in the therapy of depressive patients. We studied effects of felbamate (15.0, 60.0 a 240.0 mg/kg, p.o.) on social, defence-escape, aggressive and locomotory behaviour in male mice in the agonistic interaction with the non-aggressive group-housed partners. We observed a dose dependent antiagressive effect of felbamate without sedation, further more, there was a significant stimulation of locomotion after the highest dose used.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems