Cell Nuclei Segmentation Using Star-Shaped Simplex Meshes

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Authors	MATULA Pavel SVOBODA David
Year of publication	2002
Type	Article in Proceedings
Conference	Biophysics of the Genome and Its Interactions
MU Faculty or unit	Faculty of Informatics
Citation
Field	Use of computers, robotics and its application
Keywords	Cell nuclei segmentation; simplex meshes; deformable models
Description	Fast, reliable and precise cell nucleus boundary reconstruction algorithm is needed for automatic measuring of topographical parameters of the large number of cells or cell nuclei. A reconstruction method based on deformation of star-shaped simplex meshes is presented. The method was used for shape reconstruction of cell nuclei of HL-60 cells stained by DAPI (the whole volume of nuclei was visible in the input 3D images) and cell nuclei of HT-29 cells (nuclear envelope, i.e. surface of nucleus boundary, was visualized using Lamin B)
Related projects:	Nuclear topology of some protooncogenes in human neutrophilic granulocytes and leukemic cells Development of new diagnostic teniques for oncology Application of computer image analysis in optical microscopy