Vliv ligandů serotoninových receptorů na metabolickou aktivitu v izolovaných perfundovaných játrech potkana

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Title in English	Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver
Authors	SLÍVA Jiří DOSTÁLEK Miroslav
Year of publication	2002
Type	Article in Proceedings
Conference	46. Studentská vědecká konference
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	izolated perfused liver; CYP2D1
Description	The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems