Effects of endocannabinoids on agonistic behaviour in mice
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Adiktologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | CB1 and CB2 cannabinoid receptor subtypes; endocannabinoids; agonistic behaviour; mice |
| Description | The present study was designed to ascertain behavioural effects of novel endocannabinoid ligand noladin ether using the model of agonistic behaviour in mice. In aggressive singly-housed mice, noladin did not show marked changes in behavioural activities. The only significant effect recorded was the significant inhibition of sociable sniffing. In timid isolates, noladin elicited a significant aggresssogenic action with the impairment of the locomotor activity. Thus, the behavioural noladin profile found did not fully resemble that of anandamide which in our earlier experiments exerted a significant antiaggressive effects using the model of mouse agonistic social interactions. |
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