Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications

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Authors

KAŇKOVÁ Kateřina MÁROVÁ Ivana STEJSKALOVÁ Andrea

Year of publication 2003
Type Article in Proceedings
Conference Stress, Signalling and Control
MU Faculty or unit

Faculty of Medicine

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords diabetes mellitus; complications; polymorphism; antioxidant
Description Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patients with type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manifestation was proved irrespective of diabetes (P=0.018 and 0.021, respectively). Frequencies of A111E GLY1 and M55L PON haplotypes were significantly different between DAMD/MD and non- DAMD/MD groups (P=0.016). Conclusions: Polymorphisms in genes encoding antioxidant enzymes could belong to cluster of genetic susceptibility risk factors for diabetic complications.
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