Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Stress, Signalling and Control |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | diabetes mellitus; complications; polymorphism; antioxidant |
| Description | Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patients with type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manifestation was proved irrespective of diabetes (P=0.018 and 0.021, respectively). Frequencies of A111E GLY1 and M55L PON haplotypes were significantly different between DAMD/MD and non- DAMD/MD groups (P=0.016). Conclusions: Polymorphisms in genes encoding antioxidant enzymes could belong to cluster of genetic susceptibility risk factors for diabetic complications. |
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