The effects of cannabinoid CB1 receptor antagonist AM 251 on locomotor/exploratory behaviour and body weight in mice

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Authors	ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra
Year of publication	2003
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	body weight; AM 251; locomotor/exploratory behaviour; mice
Description	The effects of the cannabinoid CB1 receptor antagonist AM 251 were assessed in adult, non-obese male mice. The changes in the behaviour recorded were aimed on locomotor/exploratory activity of mice in the open field test. The daily administration of AM 251 reduced dose-dependently and significantly body weight, while did not significantly affect locomotor/exploratpry activities neither after acute nor repeated administration.
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