Kombinace antidepresiv v klinické praxi
| Title in English | Combination of antidepresants in clinical practice |
|---|---|
| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | combination antidepressants; residual symptoms; side effects; pharmacoresistant depression; dual action antidepressants; serotonin syndrome |
| Description | Consequences of abailability of new antidepressants(AD) are not completely mapped. In the case of unsuccessful first treatment cure, most frequently SSRI, there are four possibilities: dose increase, augmentation, switch to another AD ( of the same or other class) and combination of ADs. The combination is used in partial responders for reduction of residual symptoms and correction of side effects of AD and a breakthrough of pharmacoresistance. Fir application of AD combination the theoretical knowledge about mechanism of efficacy and various pressures - from the site of patients, its family, financial reasons are important. There have been realised minimum controlled studies concerning to this problem. The combination of SSRI with another AD is one the most ofte used, also by primary care doctors. From the theoretical and practical point of view the most justified it is the combination of SSRI and receptor modulators. One from possible risks is the serotonin syndrome. |
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