Antidepressive-like felbamate effects on exploratory behaviour in mice
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Homeostasis |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | agonistic interactions; felbamate; antidepressant; animal model |
| Description | The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinically used antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate. |
| Related projects: |