Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Memory in Living Systems |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Fos; Myb; proliferation; differentiation; apoptosis |
| Description | c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell. |
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