Mapování vazebné nerovnováhy SNP v RAGE a GLY1 genech a identifikace haplotypového markeru diabetické nefropatie u T2DM v České populaci

Investor logo

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Title in English Mapping of linkage disequilibrium of SNPs in the RAGE and GLY1 genes and identification of haplotype disease marker of diabetic nephropathy in T2DM in Czech population
Authors

KAŇKOVÁ Kateřina ZNOJIL Vladimír STEJSKALOVÁ Andrea HERTLOVÁ Miluše KRUSOVÁ Darja

Year of publication 2004
Type Article in Periodical
Magazine / Source Diabetologie, metabolismus, endokrinologie, výživa
MU Faculty or unit

Faculty of Medicine

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords diabetes; complications; nephropathy; association; RAGE; glyoxalasis
Description We conclude that RAGE haplotype consisting of -429C/-374T/+2184G alleles can be regarded one of genetic risk factors of susceptibility and progression of diabetic nephropathy (DN). Character of asociation, frequency of risk haplotype and gain-of-function type of effect are in agreement with the results of segregation analyses of DN in T2DM.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.