Mapování vazebné nerovnováhy SNP v RAGE a GLY1 genech a identifikace haplotypového markeru diabetické nefropatie u T2DM v České populaci

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Title in English	Mapping of linkage disequilibrium of SNPs in the RAGE and GLY1 genes and identification of haplotype disease marker of diabetic nephropathy in T2DM in Czech population
Authors	KAŇKOVÁ Kateřina ZNOJIL Vladimír STEJSKALOVÁ Andrea HERTLOVÁ Miluše KRUSOVÁ Darja
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Diabetologie, metabolismus, endokrinologie, výživa
MU Faculty or unit	Faculty of Medicine
Citation
Field	Endocrinology, diabetology, metabolism, nutrition
Keywords	diabetes; complications; nephropathy; association; RAGE; glyoxalasis
Description	We conclude that RAGE haplotype consisting of -429C/-374T/+2184G alleles can be regarded one of genetic risk factors of susceptibility and progression of diabetic nephropathy (DN). Character of asociation, frequency of risk haplotype and gain-of-function type of effect are in agreement with the results of segregation analyses of DN in T2DM.
Related projects:	Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus Molecular pathophysiology of multigene diseases