Genetic variations in the human gelatinase A (MMP-2) promoter are not associated with susceptibility to, and severity of, chronic periodontitis

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Authors	IZAKOVIČOVÁ HOLLÁ Lydie FASSMANN Antonín VAŠKŮ Anna PÁVKOVÁ GOLDBERGOVÁ Monika BERÁNEK Michal ZNOJIL Vladimír VANĚK Jiří VÁCHA Jiří
Year of publication	2005
Type	Article in Periodical
Magazine / Source	J Periodontol
MU Faculty or unit	Faculty of Medicine
Citation
Field	ORL, ophthalmology, stomatology
Keywords	gelatinase A; MMP-2; gene; polymorphism; haplotype; periodontitis
Description	Gelatinase A (matrix metalloproteinase-2, MMP-2) has been shown to play an important role in the pathogenesis of several disorders, including periodontal diseases. In this study, we test the hypothesis that variations in this gene influence the development and severity of chronic periodontitis.
Related projects:	Molecular pathophysiology of multigene diseases