STANOVENÍ TOLBUTAMIDU JAKO MARKERU METABOLICKÉ AKTIVITY CYP2C6/11

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Title in English Determination of tolbutamide as a probe substrate of metabolic activity CYP2C6/11
Authors

JUŘICA Jan

Year of publication 2004
Type Article in Proceedings
Conference Sborník abstrakt 48. Vědecké konference
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Tolbutamid; CYP2C9
Description The aim of the project was to develop simple, sensitive and reproducible method for determination of tolbutamide and hydroxytolutamide from perfuse rat liver medium. Hydroxylation of tolbutamide is used as a valuable tool for measurement of metabolic activity of the 2C6/11 isoform of cytochrome P-450 in rats (CYP2C6/11) The determination was performed with HPLC. This method employs an internal standard. This method is applicable for measurement the activity of CYP 2C6/11.
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