MIDAZOLAM JAKO SELEKTIVNÍ MARKER PODRODINY 3A CYTOCHROMU P450; FARMAKOKINETICKÁ CHARAKTERISTIKA MIDAZOLAMU

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Title in English Midazolam as a probe substrate of 3A subfamily CYP-450, pharmacological parameters of midazolam
Authors

JUŘICA Jan DOSTÁLEK Miroslav PISTOVČÁKOVÁ Jana MINAŘÍKOVÁ Veronika HANESOVÁ Mariana HADAŠOVÁ Eva TOMANDL Josef

Year of publication 2004
Type Article in Proceedings
Conference Sborník abstrakt, Medifórum
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Midazolam; CYP-450
Description The aim of the project was to develop HPLC method for determination of midazolam and its three metabolites, 1- and 4-hydroxymidazolam and 1,4-dihydroxymidazolam from perfuse rat liver medium. Hydroxylation of midazolam is used as a valuable tool for measurement of metabolic activity of the 3A1/2 isoform of cytochrome P-450 in rats (CYP3A1/2)This method is simple, rapid, sensitive and applicable for modeling and description of possible pharmacological interactions on rat CYP3A1/2 or it`s human orthologue CYP3A4/5, respectively. In the second part of the project, there was performed pharmacokinetic study after i.v. administration of midazolam.
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