Association of tumour necrosis factor-alpha, lymphotoxin-alpha and HLA-DRB1 gene polymorphisms with Lofgrens syndrome in Czech patients with sarcoidosis

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Authors

MRAZEK František IZAKOVIČOVÁ HOLLÁ Lydie HUTYROVÁ Beata ZNOJIL Vladimír VAŠKŮ Anna KOLEK Vítězslav WELSH KI VÁCHA Jiří DU BOIS R.M. PETŘEK Martin

Year of publication 2005
Type Article in Periodical
Magazine / Source Tissue Antigens
MU Faculty or unit

Faculty of Medicine

Citation
Field Epidemiology, infectious diseases and clinical immunology
Keywords association; cytokine polymorphism; HLA; LT-alpha; MHC; SNP; TNF
Description Sarcoidosis is a granulomatous disorder showing a clear association with MHC (HLA) class I and class II genes. In order to investigate whether polymorphisms of nearby pro-inflammatory genes located within the MHC class III region may also contribute to susceptibility to sarcoidosis or to its clinical manifestation, tumour necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha) genes were chosen for analysis in a case-control study.
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