Action potential voltage clamp method used in analysis of rate-dependent changes of action potential
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Analysis of Biomedical Signals and Images |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | action potential voltage clamp; rate dependence; method; action potential |
| Description | Ionic currents responsible for rate-dependent changes of action potetial (AP) waveform were analyzed using AP voltage clamp method in isolated rat ventricular myocytes. The L-type calcium current ICa-L and the transient outward current Ito were found to underlie rate-dependent variability of AP duration. In addition, the fast sodium current INa played a significant role under the effect of the class I antiarrhythmic drug ajmaline, very likely as a consequence of its use-dependent block. |
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