Effect of ajmaline on transient outward current Ito in rat ventricular myocytes

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří

Year of publication 2005
Type Article in Periodical
Magazine / Source General Physiology and Biophysics
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords ajmaline; transient outward current; rat; frequency dependence
Description The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage.
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