Effect of ajmaline on transient outward current Ito in rat ventricular myocytes
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | General Physiology and Biophysics |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | ajmaline; transient outward current; rat; frequency dependence |
| Description | The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage. |
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