Kanabinoid metanandamid vyvolává u myší zkříženou sensitizaci k antiagresivnímu účinku metamfetaminu, ne však morfinu

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Title in English Cannabinoid methanandamide elicits in mice cross-sensitization to antiaggressive effect of methamphetamin but not of morphine
Authors

LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Adiktologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; cross-sensitization; methamphetamine; morphine; methanandamide
Description The study was focused on development of behavioural sensitization to antiaggressive effects of methamphetamine and morphine after their repeated administration, and on a possibility of cross-sensitization with repeated administration of cannabinoid CB1 receptor agonist methanandamide in mice. In aggressive animals, repeated administration of methamphetamine but not of morphine produced sensitization to antiaggressive effect. In animals pre-treated with methanandamide the phenomenon of cross-sensitization occurred as increased antiaggressive efficacy of metamphetmaine. The parallel was not confirmed with morphine in this study.
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