Význam genotypu a fenotypu CYP2D6 při léčbě paroxetinem

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Title in English	Impact of genotype and phenotype CYP2D6 in paroxetine treatment
Authors	ŽOURKOVÁ Alexandra HADAŠOVÁ Eva PILAŘOVÁ Lucie RAVČUKOVÁ Barbora ROBEŠ Miroslav
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Psychiatrie časopis pro moderní psychiatrii
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	genotype-phenotype-CYP2D6-paroxetine-sexual dysfunction
Description	The aim of study was comparison of distribution of therapeutic efficacy and side effects including sexual dysfunction in long term paroxetine treatment within 50 patients genotyped and phenotyped to determine their CYP2D6 metabolic status.No variation in therapeutic efficaccy and common adverse effects between subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction was recorded among patients with a PM phenotype.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems