Effect of fluoxetine on methamphetamine biodegradation in methamphetamine dependence

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Authors	JUŘICA Jan DOSTÁLEK Miroslav PISTOVČÁKOVÁ Jana TOMANDL Josef LINHART Igor ŠULCOVÁ Alexandra HADAŠOVÁ Eva
Year of publication	2005
Type	Article in Periodical
Magazine / Source	European Neuropsychpharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	metamphetamine; fluoxetine; dependence; pharmacokinetics
Description	Fluoxetine and the combined treatment with methamphetamine inhibited oxidative metabolism by the CYP2C6 and CYP2D2 and CYP3A1/2. Fluoxetine therapy could slow down biodegradation of methamphetamine in methamphetamine dependent subjects and thus the psychotropic effect of the drug can be maintained by smaller doses.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems