Srovnání účinků citalopramu a vybraných antiepileptik v modelu sociálního stresu u myší
| Title in English | Comparison of the effects of citalopram and those of selected antiepileptic drugs in the mouse model of social stress |
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| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Československá fyziologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | social stress; citalopram; antiepileptic; antidepressant; mice; animal model |
| Description | To compare behavioural effects of valproate, carbamazepine, lamotrigine, gabapentine and citalopram we used the mouse model of social stress based on the suppression of locomotor-exploratory activity in a male group-housed mouse repeatedly defeated in social interactions with an aggressive singly-housed partner. Antidepressants were shown to disinhibit the social defeat-induced supression of the locomotion in the open field test. Citalopram, valproate and carbamazepine exhibited similar antidepressant-like effects in this model of social stress, unlike lamotrigine and gabapentine. |
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