Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study

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Authors

PÁSEK Michal ŠIMURDA Jiří ORCHARD Clive CHRISTÉ Georges

Year of publication 2005
Type Article in Proceedings
Conference Computers in cardiology 2005
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords cardiac cell; tubular system; quantitative modelling
Description Experimental data related to the transverse - axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca within the tubular lumen decreases the intracellular Ca-load and intracellular Ca-transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed.
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