Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model

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Authors	CHRISTÉ Georges RESTIER L. CHAHINE M. CHEVALIER P. PÁSEK Michal
Year of publication	2005
Type	Article in Proceedings
Conference	Computers in cardiology 2005
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	cardiac cell persistent; sodium current; quantitative modelling
Description	In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 current. We explored the effects of such a change on the intracellular ionic homeostasis and arrhythmogenesis in a model of guinea-pig cardiac ventricular cell.
Related projects:	Early diagnostics and treatment of cardiovascular diseases