Improved 3D Reconstruction of Interphase Chromosomes Based on Nonlinear Diffusion Filtering
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Proceedings of PDE-Based Image Processing and Related Inverse Problems |
| MU Faculty or unit | |
| Citation | |
| Field | Informatics |
| Keywords | Nonlinear diffusion filtering; PDE based image processing; interphase chromosomes; biomedical application |
| Description | A recently published method for 3D reconstruction of interphase chromosomes based on the fast marching method was extended. A kind of anisotropic diffusion filtering, namely the balanced forward-backward diffusion filtering, was added to the preprocessing phase of the algorithm. The method for finding an optimal arrival time was also modified. The anisotropic diffusion filtering can suppress inhomogeneities in chromosome staining while edges in images are preserved. This leads to better performance for chromosomes that are close to each other. |
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