A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF

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Authors

JONES Sarah FLORENCE Margaret ELLIS Ian KAY Richard COX Jacqueline KAŇKOVÁ Kateřina SCHOR Seth SCHOR Ana

Year of publication 2006
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibited by MSF inhibitor.
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