Hipokampus, morfologie mozku a schizofrenie

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Title in English Hippocampus, Structure of the Brain and Schizophrenia
Authors

KAŠPÁREK Tomáš PŘIKRYL Radovan SCHWARZ Daniel KUČEROVÁ Hana ČEŠKOVÁ Eva

Year of publication 2006
Type Article in Periodical
Magazine / Source Časopis lékařů českých
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords schizophrenia; endophenotype; morphology; volumetry; computational neuroanatomy
Description Schizophrenia is a clinically heterogeneous state without clearly defined pathogenesis. This limits the classification approaches with consequent lack of ability for individual treatment strategies. It becones evident that hippocampus is a key structure in the neuropathology of schizophrenia and a concept of hippocampal reduction as an endophenotype of schizophrenia was established. The biggest support came from MRI volumetric studies. Despite that, due to some inconsistent findings, clinical consequences of hippocampal shrinkage are not yet clear. Contemporary methods of brain imaging (computation morphometry), voxel-based morphometry) coud help us to outline the concept of schizophrenia and to clarify the clinical consequences of brain structure changes.
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